Our group seeks to elucidate general principles of gene expression and protein complex assembly. We are trying to understand how changes in cell state are regulated at the transcriptomic and epigenetic levels by studying the differentiation of mouse T helper (Th) cells and embryonic stem cells (mESC) at the single cell level. We use and develop both computational and experimental approaches in the field of single cell genomics to address our questions. We also study protein complexes in terms of their 3D structure, structural evolution and the principles underlying protein-complex formation and organisation.
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Transcriptional regulation and gene expression
We study the processes that control cell-specific gene expression in both embryonic stem cells and in T lymphocytes. This enables us to ask questions about the mechanisms that maintain stem-cell pluripotency and the ways that cells make fate decisions within the immune system.
It is clear that differences between cells within seemingly homogeneous populations can be crucial in many biological processes. We work with cutting-edge techniques that enable us to study cell populations at single-cell resolution. We apply these techniques to better understand our areas of interest and we also develop novel computational approaches to analyse single-cell data.
We are fascinated by the mechanisms that control the development, differentiation and fate choices of CD4+ T lymphocytes. We study these cells at the single-cell level to understand their behaviour during immune responses and also the role of the cells' specific T cell receptors.
We investigate the principles that govern the folding and assembly of protein complexes. Most recently, by analysing the tens of thousands of protein complexes for which three-dimensional structures have already been experimentally determined, we found repeating patterns in the assembly transitions that occur, which could be organized into a periodic table.