A diverse team of scientists from across the world
Sarah Teichmann (Group Leader)
Sarah Teichmann is interested in global principles of protein interactions and gene expression . In particular, her research now focuses on genomics and immunity. Sarah did her PhD at the MRC Laboratory of Molecular Biology, Cambridge, UK and was a Beit Memorial Fellow at University College London. She started a group at the MRC Laboratory of Molecular Biology in 2001. In 2013, she moved to the Wellcome Trust Genome Campus in Hinxton/Cambridge, where her group was joint between the EMBL-European Bioinformatics Institute and the WT Sanger Institute. From 2016, Sarah is the Head of Cellular Genetics at the WT Sanger Institute. Sarah is an EMBO member and fellow of the Academy of Medical Sciences, as well as a Fellow of the International Society of Computational Biology. Her work has been recognized by a number of prizes, including the Lister Prize, Biochemical Society Colworth Medal, Royal Society Crick Lecture and EMBO Gold Medal.
Kerstin Meyer (Principal Staff Scientist in Cellular Genetics, working with the Teichmann group and Human Cell Atlas projects)
Kerstin is interested in understanding the regulation of gene expression in health and disease. Kerstin did her undergraduate degree in Biochemistry at Imperial College, London, followed by a PhD in immunology at the MRC Laboratory of Molecular Biology. Since then she has worked at the University of Cambridge studying aspects of gene regulation in immunology and gene regulatory networks in breast and lung cancer. Her appointments have included a Royal Society University Research Fellowship and a Group Leader position at the Department of Oncology. She is currently co-ordinating the Human Cell Atlas efforts at the Sanger Institute.
Lira Mamanova (Research Manager)
Lira manages the 'wet lab' side of the research group. She was previously working in Sequencing R&D.
Anna Wilbrey-Clark (Staff Scientist)
Anna Wilbrey-Clark is a Staff Scientist working on the Human Cell Atlas project. She is a ‘wet-lab’ scientist interested in using single cell sequencing and spatial / imaging techniques to understand the cell type composition of human organs. Anna joined the lab in 2017, having previously completed a PhD in Molecular Biology / Neuroscience at the Babraham Institute and worked for 7 years in the pharmaceutical industry.
Krzysztof Polański (Staff Scientist)
Krzysztof Polański is a computational Staff Scientist working on the Human Cell Atlas project. He specialises in single cell and spatial data analysis, with particular interests including batch correction and clustering algorithms. Krzysztof got a PhD in Systems Biology from the University of Warwick in 2015, with his thesis focusing on regulatory events in Arabidopsis response to stress, and has joined the lab in 2017.
Eirini Sofia Fasouli (Research Assistant)
Eirini Sofia Fasouli graduated BSc in Molecular Biology and Genetics from Democritus University of Thrace, Greece and received an MSc in Biopharmaceuticals from King’s College, London. During her MSc her research focus was on the epigenetic regulation on energy deficiency in Neurodegenerative diseases, more specifically in Parkinson’s disease.
She joined Teichmann Group in Wellcome Trust Sanger Institute in collaboration with Open Targets in 2017 as Research assistant in Cellular Genetics for the Human Lung Atlas. She is currently working in an automated workflow for a high-throughput single cell transcriptomics for Human Cell Atlas.
Kylie is interested in the dynamics of T cell responses during infectious disease. In particular, she is applying single cell technologies and computational approaches to understand how gene expression signatures, cell-cell interactions and tissue localisation can influence these responses.
Kylie received a BSc (Hons) from the University of Queensland and completed a PhD in the Malaria Immunology Laboratory at QIMR Berghofer Medical Research Institute, Australia.
Chichau did his BSc in Harbin Institute of Technology, and his PhD in Institute of Biophysics, Chinese Academy of Science. Before joining the Teichmann lab, he did postdoc with Eric Westhof in France. Chichau did protein structure prediction for his PhD and started to organize world-wide RNA structure prediction assessment (RNA-Puzzles) afterwards. He is trying to integrate different types of single cell RNA-Seq data and to visualize the data. His researches focus on single cell RNA-Seq, RNA structure and protein-RNA interaction.
Jongeun Park has studied RNA biology during his PhD in Dr. V. Narry Kim's lab at the Seoul National University, South Korea. He joined Dr. Sarah Teichmann's group in 2017 to join the Human Cell Atlas project. He is studying the development of human immune system by applying single cell technology. He is also interested at developing computational methods for integrative data analysis.
Mirjana did her BSc (Computer Science) and MSc (Bioinformatics) in Macedonia. She then completed her PhD in the field of computational cancer immunology at the Medical University of Innsbruck.
Mirjana is interested in the role of the immune system in cancer progression. Here at the Teichmann Lab, she is applying single cell technologies and computational approaches to study the cellular diversity within the tumour microenvironment and to understand the underlaying mechanisms involved in mediating interactions between tumour and immune cells.
Carlos is interested in studying the innate immune system at the single cell level. He received his B.Sc from the National Autonomous University of Nicaragua - León where he became interested in molecular biology and genomics. In 2011, he joined Bjorn Andersson’s lab at Karolinska Institutet in Stockholm, Sweden to work with genome assembly of conifers and in 2012 he started his Ph.D studying parasite population genomics, genome assembly of salamanders and single cell RNA-Seq data analysis. In 2016 he started a postdoc at the Francis Crick Institute in London applying statistical learning methods to study host-pathogen interactions in Malaria.
He joined the Teichmann lab in September 2018 and is applying machine learning methods for multi-omics data integration, trajectory inference and cell differentiation of the innate immune system.
Waradon received his BA in Biochemistry from Columbia University with some research work on toll-like receptors and innate immunity. He completed his PhD in Immunology with Vijay Kuchroo at Harvard University, working on applying single cell RNA-seq technology to investigate ontogeny, function and regulation of follicular T cells.
He joined the Teichmann’s group in 2019, focusing on using single cell RNA-seq technology to better understand immunity against dengue virus with respect to their pathogenicity.
Peng studied Statistics and Biochemistry at the University of Hong Kong for his Bachelor’s degree. He then went on to obtain his PhD degree at California Institute of Technology. He is now using genomics and systems biology approaches to understand transcriptional regulation and their impacts on human tissue development and pathophysiology
Cecilia Dominguez Conde
Cecilia joined the Teichmann lab in 2019 to study human immunity across lymphoid and non-lymphoid tissues and to unravel the clonal distributions of T and B lymphocytes.
After completing a degree in Pharmacy in the University of Seville, Cecilia went on to study an MSc in Molecular Medicine at University College London and a PhD in Immunology at the Research Centre for Molecular Medicine of the Austrian Academy of Sciences. Her PhD work focused on dissecting the genetic cause of molecularly undiagnosed primary immunodeficiencies, which led to the discovery of human DOCK2 and POLD immunodeficiencies.
Tomas Pires de Carvalho Gomes
Tomás is a computational PhD student interested in T cell biology and differentiation, and which pathways and transcription factors regulate the cell fate decisions involved. His core training is Molecular Biology, for which he did a BSc in Lisbon, Portugal, followed by an MSc in Bioinformatics and Computational Biology, also in Lisbon. In his master thesis he worked in transcription in human cells and how RNA Polymerase II modifications during RNA synthesis related to different RNA processing stages - such as splicing and termination, by analysing mNET-seq or RNA-seq data from different cellular fractions.
Raghd studied her Bachelor's degree (Natural Sciences - Pathology) and Master's degree (Systems Biology) at the University of Cambridge.
In 2015, she joined the BBSRC DTP Programme, and is carrying out her PhD under the joint supervision of Sarah Teichmann and Oliver Stegle (European Bioinformatics Institute). Raghd will be investigating the cell-to-cell and person-to-person variability in the human innate immune response using genetic and transcriptomic data.
Daniel focuses on how computational methods and mathematical modelling can be used to study cell fate dynamics at the single cell level.
He has a background in Physics and Computational Biology. For his PhD he is jointly supervised by Sarah Teichmann and Benjamin Simons.
Rasa has completed an integrated BSc and MSc degree in Molecular and Cellular biology with Biotechnology at the University of Glasgow. She is a Wellcome Trust Sanger Institute PhD student jointly supervised by Sarah Teichmann, Ludovic Vallier and Matthias Zilbauer.
Rasa has a wet lab background and an interest in computational scRNA-seq analyses. As part of her PhD project, she is working on deciphering dynamics of transcriptional control and cell fate decisions during tissue patterning and organogenesis.
Veronika has a long-standing interest in using the power of computational approaches and single-cell RNA-sequencing to understand the mechanism of ageing changes.
Before joining the group, Veronika studied expression variability in the human brain with age as a trainee in Janet Thornton group at European Bioinformatics Institute, UK and looked into the cellular mechanisms of the Hutchinson-Gilford Progeria - rare accelerated ageing disease - as an intern in Oliver Dreesen group, IMB, Singapore. Veronika has completed M.Sc. and B.Sc. training in Molecular Biology and Genetics at Taras Shevchenko National University of Kyiv, Ukraine. Veronika is jointly supervised by Sarah Teichmann and Inigo Martincorena.
Zhihan joined the Teichmann lab in early 2019 after transferring from MRC Biostatistics Unit, he will proceed with the PhD study mainly in the method development. Zhihan has a mathematical background, he completed a Bachelor degree in Mathematics and Statistics at Imperial College London and a Master of Advanced Study degree in Mathematical Statistics (known as Part III) at the University of Cambridge.
He works on the inference of Gene Regulatory Network based on single-cell RNA-seq expression matrix. The aim is to develop or modify methods to infer the regulation between transcription factors and target genes. The methods of his interest are mainly in the area of deep learning, such as variational autoencoder.
Long Term Visitors
Monika Litvinukova is a visiting PhD student from Norbert Hubner’s group at the Max-Delbrueck-Center for Molecular Medicine (MDC) in Berlin, Germany. The Hubner lab studies the genetics and genomics of cardiovascular and metabolic diseases and collaborates with the Teichmann lab in the framework of the Human Cell Atlas.