Group leader

Sarah Teichmann (Group Leader)

Sarah Teichmann is interested in global principles of protein interactions and gene expression . In particular, her research now focuses on genomics and immunity. Sarah did her PhD at the MRC Laboratory of Molecular Biology, Cambridge, UK and was a Beit Memorial Fellow at University College London. She started a group at the MRC Laboratory of Molecular Biology in 2001. In 2013, she moved to the Wellcome Trust Genome Campus in Hinxton/Cambridge, where her group was joint between the EMBL-European Bioinformatics Institute and the WT Sanger Institute. From 2016, Sarah is the Head of Cellular Genetics at the WT Sanger Institute. Sarah is an EMBO member and fellow of the Academy of Medical Sciences, as well as a Fellow of the International Society of Computational Biology. Her work has been recognized by a number of prizes, including the Lister Prize, Biochemical Society Colworth Medal, Royal Society Crick Lecture and EMBO Gold Medal.

CV | Google Scholar


Staff

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Kerstin Meyer (Principal Staff Scientist in Cellular Genetics, working with the Teichmann group and Human Cell Atlas projects)

Kerstin is interested in understanding the regulation of gene expression in health and disease. Kerstin did her undergraduate degree in Biochemistry at Imperial College, London, followed by a PhD in immunology at the MRC Laboratory of Molecular Biology. Since then she has worked at the University of Cambridge studying aspects of gene regulation in immunology and gene regulatory networks in breast and lung cancer. Her appointments have included a Royal Society University Research Fellowship and a Group Leader position at the Department of Oncology. She is currently co-ordinating the Human Cell Atlas efforts at the Sanger Institute.


Xi Chen (Senior Staff Scientist)

Xi Chen did his BSc in Experimental Medicine in Peking University Health Science Centre in Beijing, where he became intereted in all the techqniues used in biochemistry and molecular biology. After graduatiion, he joined Prof. Andy Sharrocks' lab at the University of Manchester as a PhD student, studying the DNA binding specificity of different Forkhead transcription factors. During his PhD, he discovered an evolutionarily conserved transcription factor complex that regulates G2/M cell cycle transition. After his PhD, he joined Dr. Sarah Teichmann's group as a postdoc to investiage T helper cell 2 (Th2) differentiation from an epigenetic point of view.

He is currently working as a Senior Staff Scientist in the Teichmann lab, where he has been trying to develop techniques to interrogate the gene expression and epigentic profiles at the single cell level. He is manly interested in incorporating gene expression and epigenetic data to understand cellular differentiation.


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Lira Mamanova (Research Manager)

Lira manages the 'wet lab' side of the research group. She was previously working in Sequencing R&D.

 


Postdocs

Tzachi Hagai

Tzachi's scientific interests lie in the intersection of evolution, regulation and protein biophysics.

In recent years, he has focused on host–virus co-evolution and interactions as a model for studying the evolution of protein–protein interactions and gene regulation. 


Johan Henriksson

Johan obtained his master degrees in mechanical/software engineering and mathematics at Chalmers University of Technology (Sweden, 2007). After a master thesis on predicting NMR responses from gel structures, and working on mathematical modeling of sympatric speciation, he completely changed gears and entered biology instead. Johan did his PhD at Karolinska institutet (2012), developing microscopy software and hardware to study gene expression patterns during C.elegans embryogenesis.

Frustrated by the throughput limitations of microscopy, he is now developing methods for large-scale mapping of transcriptomic regulation - including CRISPR screenings and custom single-cell chemistries. His research is supported by a grant from the Swedish Research Council


Gozde Kar

Gozde did her PhD at Koc University, Istanbul, Turkey where she has specialized in structural bioinformatics and performed large-scale computational studies on protein recognition. After joining Teichmann lab, she has worked on understanding the relationship between chromatin state and stochastic gene expression at the single-cell level. She is also a member of Center for Therapeutic Target Validation team, where she uses single cell transciptomics to identify immune cells and molecules involved in asthma disease.


Felipe Vieira Braga

Felipe Vieira Braga studied in Brazil, where he did his BSc in pharmacy. After that he moved to The Netherlands where he did his MSc at Radboud University Nijmegen and PhD at the University of Amsterdam. Felipe specializes in studying the human immune system, with special interest in human cytotoxic lymphocytes (T and NK cells). During his PhD he worked on transcription and metabolic regulation of primary CD8 T-cells. At the Teichmann Lab Felipe uses single cell technologies to understand the heterogeneity of the human T-cell compartment and how this heterogeneity can improve our understanding of immune responses against pathogens in humans. Additionaly, Felipe is part of the Centre for Therapeutic Target validation, where he uses single cell technologies to identify new therapeutic targets for treating Asthma.


Roser Vento

Roser is interested in the influence cellular micro-environments may have on defining unique immune cell identities and responses. After completing her PhD program in Esteban Ballestar’s lab in Barcelona, she joined the Teichmann Group as an EMBO post-doctoral fellow. Here, she is combining her knowledge of both wet and dry skills to study immune cell communication in different human immune niches.


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Kylie James

Kylie is interested in the dynamics of T cell responses during infectious disease. In particular, she is applying single cell technologies and computational approaches to understand how gene expression signatures, cell-cell interactions and tissue localisation can influence these responses.

Kylie received a BSc (Hons) from the University of Queensland and completed a PhD in the Malaria Immunology Laboratory at QIMR Berghofer Medical Research Institute, Australia.


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Chichau Miau

Chichau did his BSc in Harbin Institute of Technology, and his PhD in Institute of Biophysics, Chinese Academy of Science. Before joining the Teichmann lab, he did postdoc with Eric Westhof in France. Chichau did protein structure prediction for his PhD and started to organize world-wide RNA structure prediction assessment (RNA-Puzzles) afterwards. He is trying to integrate different types of single cell RNA-Seq data and to visualize the data. His researches focus on single cell RNA-Seq, RNA structure and protein-RNA interaction.


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Jongeun Park

Jongeun Park has studied RNA biology during his PhD in Dr. V. Narry Kim's lab at the Seoul National University, South Korea. He joined Dr. Sarah Teichmann's group in 2017 to join the Human Cell Atlas project. He is studying the development of human immune system by applying single cell technology. He is also interested at developing computational methods for integrative data analysis.

 


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Mirjana Efremova

Mirjana did her BSc (Computer Science) and MSc (Bioinformatics) in Macedonia. She then completed her PhD in the field of computational cancer immunology at the Medical University of Innsbruck.

Mirjana is interested in the role of the immune system in cancer progression. Here at the Teichmann Lab, she is applying single cell technologies and computational approaches to study the cellular diversity within the tumour microenvironment and to understand the underlaying mechanisms involved in mediating interactions between tumour and immune cells.


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Carlos Talavera-Lopez

Carlos is interested in studying the innate immune system at the single cell level. He received his B.Sc from the National Autonomous University of Nicaragua - León where he became interested in molecular biology and genomics. In 2011, he joined Bjorn Andersson’s lab at Karolinska Institutet in Stockholm, Sweden to work with genome assembly of conifers and in 2012 he started his Ph.D studying parasite population genomics, genome assembly of salamanders and single cell RNA-Seq data analysis. In 2016 he started a postdoc at the Francis Crick Institute in London applying statistical learning methods to study host-pathogen interactions in Malaria.  

He joined the Teichmann lab in September 2018 and is applying machine learning methods for multi-omics data integration, trajectory inference and cell differentiation of the innate immune system.


PhD Students

Tomas Pires de Carvalho Gomes

Tomás is a computational PhD student interested in T cell biology and differentiation, and which pathways and transcription factors regulate the cell fate decisions involved. His core training is Molecular Biology, for which he did a BSc in Lisbon, Portugal, followed by an MSc in Bioinformatics and Computational Biology, also in Lisbon. In his master thesis he worked in transcription in human cells and how RNA Polymerase II modifications during RNA synthesis related to different RNA processing stages - such as splicing and termination, by analysing mNET-seq or RNA-seq data from different cellular fractions.


Raghd Rostom

Raghd studied her Bachelor's degree (Natural Sciences - Pathology) and Master's degree (Systems Biology) at the University of Cambridge.  

In 2015, she joined the BBSRC DTP Programme, and is carrying out her PhD under the joint supervision of Sarah Teichmann and Oliver Stegle (European Bioinformatics Institute). Raghd will be investigating the cell-to-cell and person-to-person variability in the human innate immune response using genetic and transcriptomic data.


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Daniel Kunz

Daniel focuses on how computational methods and mathematical modelling can be used to study cell fate dynamics at the single cell level.

He has a background in Physics and Computational Biology. For his PhD he is jointly supervised by Sarah Teichmann and Benjamin Simons.
 


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Rasa Elmentaite

Rasa has completed an integrated BSc and MSc degree in Molecular and Cellular biology with Biotechnology at the University of Glasgow. She is a Wellcome Trust Sanger Institute PhD student jointly supervised by Sarah Teichmann, Ludovic Vallier and Matthias Zilbauer.  

Rasa has a wet lab background and an interest in computational scRNA-seq analyses. As part of her PhD project, she is working on deciphering dynamics of transcriptional control and cell fate decisions during tissue patterning and organogenesis.


Long Term Visitors

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Hongbo Zhang

Hongbo Zhang is a visiting professor working at the Sun Yat-Sen University, China. He leads a research team focusing on stem cell metabolism and fate decision in development and aging. Hongbo Zhang got his PhD degree from the Swiss Federal Institute of Technology Lausanne (EPFL). Before starting his own research group in China, he did a short postdoc training with Dr. Sarah Teichmann.

Hongbo Zhang currently works closely with Teichmann Lab in several projects within the framework of the Human Cell Atlas.


Monika Litvinukova

Monika Litvinukova is a visiting PhD student from Norbert Hubner’s group at the Max-Delbrueck-Center for Molecular Medicine (MDC) in Berlin, Germany. The Hubner lab studies the genetics and genomics of cardiovascular and metabolic diseases and collaborates with the Teichmann lab in the framework of the Human Cell Atlas.