A diverse team of scientists from across the world
Sarah Teichmann (Group Leader)
Sarah Teichmann is interested in global principles of protein interactions and gene expression . In particular, her research now focuses on genomics and immunity. Sarah did her PhD at the MRC Laboratory of Molecular Biology, Cambridge, UK and was a Beit Memorial Fellow at University College London. She started a group at the MRC Laboratory of Molecular Biology in 2001. In 2013, she moved to the Wellcome Trust Genome Campus in Hinxton/Cambridge, where her group was joint between the EMBL-European Bioinformatics Institute and the WT Sanger Institute. From 2016, Sarah is the Head of Cellular Genetics at the WT Sanger Institute. Sarah is an EMBO member and fellow of the Academy of Medical Sciences, as well as a Fellow of the International Society of Computational Biology. Her work has been recognized by a number of prizes, including the Lister Prize, Biochemical Society Colworth Medal, Royal Society Crick Lecture and EMBO Gold Medal.
Xi Chen (Senior Staff Scientist)
Xi Chen did his BSc in Experimental Medicine in Peking University Health Science Centre in Beijing, where he became intereted in all the techqniues used in biochemistry and molecular biology. After graduatiion, he joined Prof. Andy Sharrocks' lab at the University of Manchester as a PhD student, studying the DNA binding specificity of different Forkhead transcription factors. During his PhD, he discovered an evolutionarily conserved transcription factor complex that regulates G2/M cell cycle transition. After his PhD, he joined Dr. Sarah Teichmann's group as a postdoc to investiage T helper cell 2 (Th2) differentiation from an epigenetic point of view.
He is currently working as a Senior Staff Scientist in the Teichmann lab, where he has been trying to develop techniques to interrogate the gene expression and epigentic profiles at the single cell level. He is manly interested in incorporating gene expression and epigenetic data to understand cellular differentiation.
Lira Mamanova (Research Manager)
Lira manages the 'wet lab' side of the research group. She was previously working in Sequencing R&D.
Guy Emerton (Senior Bioinformatician)
Guy did his B.Eng (Chemical) and MSc. (Biotechnology) in South Africa, and has varying experience in Software Development, Chemometrics and Bioinformatics.
He is busy building systems at the Teichmann Group to streamline data processing and analysis.
Tzachi's scientific interests lie in the intersection of evolution, regulation and protein biophysics.
In recent years, he has focused on host–virus co-evolution and interactions as a model for studying the evolution of protein–protein interactions and gene regulation.
Johan obtained his master degrees in mechanical/software engineering and mathematics at Chalmers University of Technology (Sweden, 2007). After a master thesis on predicting NMR responses from gel structures, and working on mathematical modeling of sympatric speciation, he completely changed gears and entered biology instead. Johan did his PhD at Karolinska institutet (2012), developing microscopy software and hardware to study gene expression patterns during C.elegans embryogenesis.
Frustrated by the throughput limitations of microscopy, he is now developing methods for large-scale mapping of transcriptomic regulation - including CRISPR screenings and custom single-cell chemistries. His research is supported by a grant from the Swedish Research Council
Gozde did her PhD at Koc University, Istanbul, Turkey where she has specialized in structural bioinformatics and performed large-scale computational studies on protein recognition. After joining Teichmann lab, she has worked on understanding the relationship between chromatin state and stochastic gene expression at the single-cell level. She is also a member of Center for Therapeutic Target Validation team, where she uses single cell transciptomics to identify immune cells and molecules involved in asthma disease.
Bidesh is an experimental biologist who joined this group in 2011. He is passionate about his discovery of immune cell-mediated de novo steroidogenesis. He is determined to understand the (patho)physiological importance of de novo steroidogenic immune cells.
Bidesh obtained his PhD (Biochemistry) from Calcutta University, India, in 2008. Before joining this group he did his postdoctoral research at the University of Wisconsin-Madison and University of Dundee.
Kedar Natarajan is interested in leveraging single cell approaches to understand the interplay between cell cycle and gene expression during differentiation and cell fate choices. Kedar works predominantly with embryonic stem cells and also with T-helper cells using a combination of different experimental and computational approaches.
Kedar received his PhD from Imperial College London while working at MRC-Clinical Sciences Centre, London on systems biology approach to dissect chromatin proteome of RNA Polymerase II in embryonic stem cells. Before that, he obtained Masters and dual Bachelor's degree from India.
Jhuma obtained her PhD from Jadavpur University, India. She is studying T cell activation/differentiation. Specifically she is interested to understand the role of IRE1a-XBP1 pathway during T cell activation.
Originally from India, Sougata did his PhD from Canada in the area of molecular biology of circadian rhythms in algae. He joined the group during mid-2014 with an EIPOD fellowship. His main interest in the group is to combine click chemistry and biochemical techniques to study the biochemistry of the steroid pregnenolone in immune cell regulation and development.
Felipe Vieira Braga
Felipe Vieira Braga studied in Brazil, where he did his BSc in pharmacy. After that he moved to The Netherlands where he did his MSc at Radboud University Nijmegen and PhD at the University of Amsterdam. Felipe specializes in studying the human immune system, with special interest in human cytotoxic lymphocytes (T and NK cells). During his PhD he worked on transcription and metabolic regulation of primary CD8 T-cells. At the Teichmann Lab Felipe uses single cell technologies to understand the heterogeneity of the human T-cell compartment and how this heterogeneity can improve our understanding of immune responses against pathogens in humans. Additionaly, Felipe is part of the Centre for Therapeutic Target validation, where he uses single cell technologies to identify new therapeutic targets for treating Asthma.
Roser is interested in the influence cellular micro-environments may have on defining unique immune cell identities and responses. After completing her PhD program in Esteban Ballestar’s lab in Barcelona, she joined the Teichmann Group as an EMBO post-doctoral fellow. Here, she is combining her knowledge of both wet and dry skills to study immune cell communication in different human immune niches.
Kylie is interested in the dynamics of T cell responses during infectious disease. In particular, she is applying single cell technologies and computational approaches to understand how gene expression signatures, cell-cell interactions and tissue localisation can influence these responses.
Kylie received a BSc (Hons) from the University of Queensland and completed a PhD in the Malaria Immunology Laboratory at QIMR Berghofer Medical Research Institute, Australia.
Chichau did his BSc in Harbin Institute of Technology, and his PhD in Institute of Biophysics, Chinese Academy of Science. Before joining the Teichmann lab, he did postdoc with Eric Westhof in France. Chichau did protein structure prediction for his PhD and started to organize world-wide RNA structure prediction assessment (RNA-Puzzles) afterwards. He is trying to integrate different types of single cell RNA-Seq data and to visualize the data. His researches focus on single cell RNA-Seq, RNA structure and protein-RNA interaction.
Ricardo Miragaia did his BSc in Biology and his MSc in Molecular Biology in the University of Lisbon. For his MSc thesis, he worked on retinal development in the Stem Cell & Neurogenesis Lab (Institute of Molecular Medicine, Lisbon). After his first experience with Bioinformatics in the Integrative Genomics of Ageing group (University of Liverpool), he enrolled in the MIT-Portugal Bioengineering Systems PhD programme.
He is currently developing his PhD project in the Teichmann Lab, where he has been working on Regulatory T cell heterogeneity and tissue residency.
Tomas Pires de Carvalho Gomes
Tomás is a computational PhD student interested in T cell biology and differentiation, and which pathways and transcription factors regulate the cell fate decisions involved. His core training is Molecular Biology, for which he did a BSc in Lisbon, Portugal, followed by an MSc in Bioinformatics and Computational Biology, also in Lisbon. In his master thesis he worked in transcription in human cells and how RNA Polymerase II modifications during RNA synthesis related to different RNA processing stages - such as splicing and termination, by analysing mNET-seq or RNA-seq data from different cellular fractions.
Raghd studied her Bachelor's degree (Natural Sciences - Pathology) and Master's degree (Systems Biology) at the University of Cambridge.
In 2015, she joined the BBSRC DTP Programme, and is carrying out her PhD under the joint supervision of Sarah Teichmann and Oliver Stegle (European Bioinformatics Institute). Raghd will be investigating the cell-to-cell and person-to-person variability in the human innate immune response using genetic and transcriptomic data.
Valentine Svensson did his BSc and MSc in mathematics at Lund University, working on geometry and computer vision. After his undergrad he joined the Swedish National Genomics Infrastructure as a scientific programmer, and later joined a methods development project as a research engineer. Currently Valentine is an EMBL PhD student in Sarah Teichmann's group at the Wellcome Trust Sanger institute. There he works on applying probabilistic machine learning models to single cell RNA-seq data to answer questions about cell fate development.
Long Term Visitors
Aik is a visiting scientist from Fluidigm. He runs collaborative projects between Sanger and Fluidigm to develop new technologies and methods in single-cell biology.
Aik obtained his PhD from University of Arizona where he engineered zinc finger proteins to make biological tools under the mentorship of Dr. David Segal. He did his postdoctoral fellowship with Dr. Brigitte Gomperts at UCLA where he studied lung biology. Prior to relocating to Cambridge, Aik worked at Fluidigm headquarters in South San Francisco where he was a technical lead in several R&D projects.